APO B 3′ HVR polymorphism in healthy population: Relationships to serum lipid levels

AbstractThe relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the connection among the CXCL12 rs501120 and rs1746048 SNPs, haplotypes, several environmental factors and serum lipid traits in the Maonan as well as Han populations. Genotyping of the two SNPs, gel electrophoresis and direct sequencing were accomplished in 1,494 distinct subjects (Maonan, 750 and Han, 744) using polymerase chain reaction and restriction fragment length polymorphism. The frequencies of genotypes as well as alleles of the two SNPs were not similar between the two ethnic groups. The rs501120 SNP was related with serum total cholesterol levels, while the rs1746048 SNP was related with serum apolipoprotein (Apo) B levels. Four haplotypes were identified, of which the rs501120A-rs1746048C haplotype was the most common. The haplotypes of rs501120A-rs1746048T increased and rs501120G-rs1746048C decreased the risk of hyperlipidemia (P < 0.001 for each), showing consistent association with the levels of serum triglyceride, ApoA1 and ApoB. These outcomes specify that the CXCL12 SNPs as well as their haplotypes are related to serum lipid levels. Different serum lipid levels between both populations may partially be related to the CXCL12 SNPs, their haplotypes along with several environmental factors.

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Retraction of: The Effect of a Gender Difference in the Apolipoprotein E Gene DNA Polymorphism on Serum Lipid Levels in a Serbian Healthy Population

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2019-8899 ◽

2020 ◽

Vol 58 (3) ◽

pp. e94

Author(s):

Sanja Stanković ◽

Sanja Glišić ◽

Dragan Alavanatić

Keyword(s):

Gender Difference ◽

Apolipoprotein E ◽

Serum Lipid ◽

Dna Polymorphism ◽

Healthy Population ◽

Lipid Levels ◽

E Gene ◽

Serum Lipid Levels ◽

Apolipoprotein E Gene

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The Effect of a Gender Difference in the Apolipoprotein E Gene DNA Polymorphism on Serum Lipid Levels in a Serbian Healthy Population

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm.2000.079 ◽

2000 ◽

Vol 38 (6) ◽

Cited By ~ 3

Author(s):

Sanja Stanković ◽

Sanja Glišic ◽

Dragan Alavanatić

Keyword(s):

Gender Difference ◽

Apolipoprotein E ◽

Serum Lipid ◽

Dna Polymorphism ◽

Healthy Population ◽

Lipid Levels ◽

E Gene ◽

Serum Lipid Levels ◽

Apolipoprotein E Gene

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Apolipoprotein B gene DNA polymorphisms (EcoRI andMspI) and serum lipid levels in the serbian healthy population: Interaction of rare alleles and smoking and cholesterol levels

Genetic Epidemiology ◽

10.1002/gepi.1370120507 ◽

1995 ◽

Vol 12 (5) ◽

pp. 499-508 ◽

Cited By ~ 12

Author(s):

S. Glišić ◽

I. Savić ◽

D. Alavantić

Keyword(s):

Apolipoprotein B ◽

Serum Lipid ◽

Dna Polymorphisms ◽

Healthy Population ◽

Lipid Levels ◽

Cholesterol Levels ◽

Serum Lipid Levels ◽

Rare Alleles ◽

Population Interaction ◽

Apolipoprotein B Gene

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Association of theKLF14rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations

BioMed Research International ◽

10.1155/2013/231515 ◽

2013 ◽

Vol 2013 ◽

pp. 1-13 ◽

Cited By ~ 6

Author(s):

Ping Huang ◽

Rui-Xing Yin ◽

Ke-Ke Huang ◽

Xiao-Na Zeng ◽

Tao Guo ◽

...

Keyword(s):

Ethnic Groups ◽

Serum Lipid ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Apo B ◽

Serum Lipid Levels ◽

Environmental Interactions ◽

Lipid Parameters

The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P<0.05). The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P<0.05) than the T allele noncarriers. Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers. The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype. Serum lipid parameters were also correlated with several environmental factors in both ethnic groups. The differences in the association ofKLF14rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions.

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Serum Apolipoprotein B/apolipoprotein A1 Ratio in Relation to Intervertebral Disc Herniation : A Cross-sectional Frequency-Matched Case-Control Study

10.21203/rs.3.rs-113468/v1 ◽

2020 ◽

Author(s):

Fei Chen ◽

Tongde Wu ◽

Song Guo ◽

Junwen Huang ◽

Qiang Fu ◽

...

Keyword(s):

Apolipoprotein B ◽

Serum Lipid ◽

Density Lipoprotein ◽

Apolipoprotein A1 ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Lipid Levels ◽

Apo B ◽

Serum Lipid Levels ◽

Apo Ai

Abstract BackgroundIn recent decades, the serum lipid profile of apolipoprotein(a) (Lp(a)) level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/ApoA1) ratio were found more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the serum lipid levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were found associated with symptomatic IDH, no studies have been conducted to date for the evaluation of the association of Apo AI, Apo B, Lp(a) and Apo B/Apo AI levels with symptomatic IDH.MaterialsA total of 1,839 Chinese patients were recruited in the present study. 918 patients were diagnosed as IDH cases and were enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B and Apo B/Apo AI were examined and analyzed.ResultsThe patients in the control group were collected randomly from patients who were matched with the baseline levels of the aforementioned lipid molecular. The patients with IDH exhibited significantly higher TC, TG, LDL, Apo B and Lp(a) levels compared with the control subjects. The percentage of high-TC, high-TG, high-LDL, high-Apo B and high-Lp(a) were significantly higher in the IDH group. However, hyperlipidaemia was not associated with the degenerated segment of the IDH (P=0.201). The odds ratios (OR) for the incidence of IDH with an elevated LDL-C, TC, TG, Lp(a), Apo B and Apo B/Apo AI were 1.583, 1.74, 1.62, 1.58, 1.49 and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a) and incidence of IDH was significant (R2LDL=0.017; R2TC=0.004; R2TG=0.015; R2Apo B=0.004; R2LP(a)=0.021) (P<0.05). ConclusionsThe present study suggests that elevated levels of serum TC, TG, LDL, Apo B, Lp(a) and Apo B/Apo AI are associated with a higher risk for IDH.

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Correlation Between the APOB rs1042034 SNP and Blood Lipid Characteristics of 2 Ethnic Groups in China

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029619892088 ◽

2019 ◽

Vol 25 ◽

pp. 107602961989208

Author(s):

Fen-Han Zhang ◽

Rui-Xing Yin ◽

Li-Mei Yao ◽

Rong-Qin Yan ◽

Li Lu ◽

...

Keyword(s):

Ethnic Groups ◽

Serum Lipid ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipid Levels ◽

Single Nucleotide ◽

Apo B ◽

Serum Lipid Levels ◽

Polymerase Chain ◽

The Relationship

The apolipoprotein (Apo) B gene ( APOB) is a susceptible gene for dyslipidemia. The purpose of this investigation was to explore the relationship between the APOB rs1042034 single-nucleotide polymorphism (SNP) and serum lipid levels in the Maonan and Han populations. A total of 598 Maonan participants and 609 Han participants were genotyped by polymerase chain reaction and restriction fragment length polymorphism, and the genotypes were also verified by sequencing. There were no differences in genotype and allele frequencies between the 2 ethnic groups or between males and females. The levels of triglyceride (TG) in Maonans were higher and high-density lipoprotein cholesterol was lower in the A allele carriers than the A allele noncarriers; the A allele carriers in Hans had higher TG levels and lower ApoA1/ApoB ratio than the A allele noncarriers ( P < .05 for all). Subgroup analysis showed that the A allele carriers in Maonan females had higher TG levels and the A allele carriers in Han females had higher TG levels and lower ApoA1/ApoB ratio than the A allele noncarriers ( P < .05 for all). In our study populations, there may be ethnicity- and/or sex-specific associations between the APOB rs1042034 SNP and serum lipid levels.

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